Common use

Sibelium is a calcium antagonist (calcium channel blocker) specifically formulated for migraine prevention in patients who experience classic migraine (with aura) or common migraine (without aura). This medication is also highly effective as a dizziness treatment for the symptomatic management of vestibular vertigo. Each Sibelium capsule contains 5.9 mg of flunarizine hydrochloride, the active ingredient responsible for its headache prophylaxis and anti-vertigo properties.

As a calcium antagonist, Sibelium works by selectively blocking calcium channels in smooth muscle cells and neurons. This mechanism stabilizes blood vessel tone in the brain and reduces the neuronal hyperexcitability that triggers migraine attacks. For patients seeking effective migraine prevention, Sibelium provides a well-established prophylactic approach backed by decades of clinical research and real-world therapeutic use.

When you buy Sibelium online from our pharmacy, you are selecting a medication with a proven track record in both headache prophylaxis and vertigo treatment. Sibelium generic versions containing flunarizine are also available, offering the same clinical benefits at a more accessible price. Whether you need to buy flunarizine for recurrent migraines, vestibular disorders, or chronic dizziness, Sibelium delivers reliable and consistent results.



Dosage and direction

The recommended dose of Sibelium for migraine prevention in adults is two 5 mg capsules (10 mg total) taken at night before bedtime. For patients over 65 years of age, the dosage should be reduced to one 5 mg capsule daily to minimize the risk of age-related side effects. Taking Sibelium at bedtime helps manage drowsiness, which is a commonly reported initial effect of this calcium antagonist.

Discontinue taking Sibelium if any signs of depressive mood, extrapyramidal symptoms, or other unacceptable adverse effects develop. Similarly, if no significant improvement in migraine frequency is observed after 2 months of initial treatment, your doctor may recommend stopping the medication. For patients who respond well to the initial headache prophylaxis phase, maintenance therapy typically consists of a 5-day course at the prescribed dose followed by 2 medicine-free days each week. This cyclical approach helps maintain effectiveness while reducing the risk of long-term side effects.



Precautions

Regular intake of Sibelium is known to cause drowsiness in many patients, particularly during the first weeks of treatment. This calcium antagonist also aggravates the effects of alcohol and other central nervous system depressants. Avoid consuming alcohol throughout your dizziness treatment or migraine prevention regimen with Sibelium.

Patients should exercise caution while driving vehicles, operating machinery, or performing other tasks that require high concentration and alertness. The sedative effects of flunarizine may impair your ability to safely perform these activities. If drowsiness persists or becomes problematic, discuss dosage adjustments or alternative headache prophylaxis options with your healthcare provider. Report any new-onset mood changes, unusual movements, or muscle stiffness to your doctor promptly.



Contraindications

Sibelium is contraindicated in patients with known hypersensitivity to flunarizine or any other component of the medication. This medication must not be used by individuals with a current or past history of depressive illness, as flunarizine may trigger or worsen depression. Patients with pre-existing extrapyramidal disorders, such as Parkinson's disease, tardive dyskinesia, or drug-induced movement disorders, should also avoid Sibelium. Additionally, this calcium antagonist is contraindicated during pregnancy and breastfeeding due to potential risks to the developing fetus and nursing infant.



Possible side effect

The most common side effects of Sibelium used for migraine prevention include drowsiness, fatigue, weight gain, and increased appetite. Some patients may also experience agitation, sedation, or tachycardia (rapid heart rate). Less frequent adverse reactions include heartburn, stomach pain, nausea, insomnia, galactorrhoea (abnormal milk production), anxiety, muscle aches, dry mouth, and skin rash.

Long-term treatment with Sibelium has been associated with depression (particularly in women) and extrapyramidal symptoms including bradykinesia (slowed movement), rigidity, akathisia (restlessness), orofacial dyskinesia, and tremor. These movement-related side effects are more commonly observed in elderly patients. If you experience any of these symptoms during your vestibular vertigo treatment, contact your physician immediately for evaluation and possible dose adjustment or discontinuation.



Drug interaction

Hepatic enzyme inducers such as carbamazepine and phenytoin can decrease blood levels of Sibelium by accelerating its metabolism in the liver. This interaction may reduce the effectiveness of your migraine prevention treatment, so dosage adjustments may be necessary. Women taking oral contraceptives concurrently with Sibelium have reported cases of galactorrhoea, and this combination should be monitored by a healthcare provider.

Inform your doctor about all medications you are taking, including prescription drugs, over-the-counter medications, herbal supplements, and vitamins. Central nervous system depressants, sedatives, and anti-anxiety medications may have enhanced effects when combined with flunarizine. Alcohol consumption should be strictly avoided during Sibelium therapy.



Missed dose

If you missed taking a dose of Sibelium, contact your doctor as a correction to your dosing schedule may be required. This is particularly important for maintaining consistent headache prophylaxis efficacy. Never double the dose of this medication to compensate for a missed dose, as this significantly increases the risk of drowsiness and other adverse effects without improving migraine prevention outcomes.



Overdose

Known symptoms of Sibelium overdose include excessive sedation, agitation, and tachycardia. Additional signs may include confusion, muscle weakness, and cardiovascular disturbances. Contact your doctor immediately or go to the nearest emergency room if you suspect that too much Sibelium was taken. Supportive care and monitoring are the primary approaches to managing flunarizine overdose.



Storage

Store Sibelium at room temperature, below 25 C (77 F), in a dry location out of reach of children and pets. Protect from direct sunlight and excessive moisture. Do not use this medication after the expiration date printed on the packaging.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.