Common use

Wellbutrin SR (bupropion) is an atypical antidepressant that belongs to a class of medications known as norepinephrine-dopamine reuptake inhibitors (NDRI). Unlike many other antidepressants that primarily target serotonin, bupropion works by blocking the reabsorption of norepinephrine and dopamine in the brain, which helps restore the natural balance of these neurotransmitters. This unique mechanism of action makes Wellbutrin SR a preferred depression treatment for patients who experience unwanted side effects from SSRI-based medications.

Doctors commonly prescribe bupropion for the treatment of major depressive disorder (MDD) and seasonal affective disorder (SAD). Wellbutrin SR is also widely recognized as an effective aid for smoking cessation, helping patients overcome nicotine dependence by reducing cravings and withdrawal symptoms. Many patients choose to buy Wellbutrin SR online because it is considered a weight neutral antidepressant — meaning it is far less likely to cause weight gain compared to other antidepressants, and some patients may even experience modest weight loss during treatment.

If you are looking to buy bupropion at an affordable price, Wellbutrin generic options offer the same active ingredient and therapeutic benefits as the brand-name version. This medicine may also be prescribed for other conditions at your doctor's discretion.



Dosage and direction

Take Wellbutrin SR (bupropion) by mouth with a full glass of water, with or without food. It is generally recommended to take doses at least 8 hours apart to maintain steady levels of the medication in your bloodstream and reduce the risk of side effects. Take the drug only as prescribed by your healthcare provider because dosage and schedule may vary depending on your condition, medical history, response to treatment, and other individual factors.

The typical starting dose of bupropion sustained-release is 150 mg taken once daily in the morning. Your doctor may gradually increase the dose to 150 mg twice daily or up to 200 mg twice daily depending on your clinical response. Avoid cutting, crushing, or chewing this medicine, as the sustained-release formulation is designed to deliver the medication gradually over time.

Do not take the medicine more often than it is prescribed. Do not give up taking it except on the advice of your doctor, even if you feel better, as abruptly stopping this antidepressant may cause discontinuation symptoms.

It may need several weeks for the medicine to reach its full therapeutic effect. Be patient and continue taking bupropion as directed.

Consult your doctor concerning the proper dose for you.



Precautions

Before taking Wellbutrin SR tell your doctor or pharmacist if you are allergic to bupropion or any of its inactive ingredients; or if you have other allergies. Provide a complete list of all medications, supplements, and herbal products you currently use.

Inform your doctor or pharmacist if you have or have ever had bipolar disorder, seizure disorders or epilepsy, eating disorders such as anorexia or bulimia, eye problems (especially glaucoma), liver disease, kidney problems, or a history of head trauma. Bupropion may lower the seizure threshold, so it is essential to discuss your full medical history with your healthcare provider before starting this NDRI medication.

Avoid drinking alcohol while being treated with Wellbutrin SR, as alcohol may increase the risk of seizures and intensify certain side effects. If you are using this antidepressant for smoking cessation, follow your doctor's guidance on the recommended timeline for quitting.

Elderly patients may be more sensitive to the side effects of this medicine and may require dosage adjustments based on kidney or liver function.

During pregnancy, this depression treatment should be used only when the potential benefits clearly outweigh the risks to the unborn child. Discuss the risks and benefits thoroughly with your doctor.

Women who are breastfeeding should consult their healthcare provider before using bupropion, as small amounts of the drug may pass into breast milk.



Contraindications

Wellbutrin SR (bupropion) should not be used by patients with a known hypersensitivity or allergic reaction to bupropion or any component of the formulation. This medication is contraindicated in patients with current or prior diagnosis of seizure disorders, eating disorders (anorexia nervosa or bulimia), or those undergoing abrupt discontinuation of alcohol, benzodiazepines, or other sedatives.

Do not take this antidepressant if you are currently using or have used a monoamine oxidase inhibitor (MAOI) within the past 14 days. Pregnant and nursing women should not use this medication without direct medical supervision. This medicine is not approved for use in children and adolescents under 18 years of age.



Possible side effect

The most common side effects of Wellbutrin SR include dry mouth, headache, nausea, constipation, insomnia, dizziness, sore throat, and increased sweating. Because bupropion is a weight neutral antidepressant, significant appetite changes and weight gain are uncommon compared to many other depression medications.

Less common side effects may include ringing in the ears (tinnitus), tremor, blurred vision, increased heart rate, skin rash, and changes in taste. Some patients report vivid dreams or difficulty sleeping, particularly if the second dose is taken too close to bedtime.

Serious side effects are rare but may include seizures, severe allergic reactions (rash, hives, swelling of the face, lips, tongue, or throat), chest pain, irregular heartbeat, confusion, hallucinations, or worsening mood and suicidal thoughts. If you experience any of these symptoms, seek medical attention immediately.

Many people using this medicine do not experience serious side effects. Turn to your doctor or pharmacist for more details about potential risks and benefits.

If you notice any effects not listed here, contact your doctor or pharmacist promptly.



Drug interaction

Tell your doctor or pharmacist about all prescription and nonprescription medications, vitamins, herbal supplements, and over-the-counter products you are currently using before starting Wellbutrin SR. Bupropion is metabolized by and inhibits the CYP2D6 enzyme, which means it can affect the blood levels of many other medications.

Bupropion can interact with:

* MAO inhibitors: Furazolidone, Isocarboxazid, Linezolid, Moclobemide, Phenelzine, Selegiline, Tranylcypromine — concurrent use is strictly contraindicated and may cause dangerous hypertensive reactions.

* Antiarrhythmics such as flecainide, propafenone, and others that are metabolized by CYP2D6.

* Antipsychotics such as haloperidol, risperidone, and thioridazine.

* Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine, paroxetine, and sertraline — combining these with bupropion may increase the risk of serotonin syndrome or seizures.

* Other medications that lower the seizure threshold, including other antidepressants, theophylline, systemic corticosteroids, and stimulants.

* Blood thinners such as warfarin — bupropion may alter INR levels.

* Medications used for diabetes, as dose adjustments may be needed.

Turn to your doctor or pharmacist for a complete list of interactions and further guidance.



Missed dose

If you have missed your dose of Wellbutrin SR, take it as soon as you remember. However, if it is near the time for the next scheduled dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for a missed one. Maintaining a consistent dosing schedule is important for the effectiveness of this antidepressant and for minimizing the risk of side effects, including seizures.



Overdose

If you think you have taken too much bupropion, seek emergency medical attention right away. The symptoms of overdose may include seizures, chest pain, nausea, vomiting, rapid or irregular heartbeat, loss of consciousness, muscle stiffness, hallucinations, and feeling light-headed or fainting. Overdose of Wellbutrin SR can be life-threatening and requires immediate medical intervention. Contact your local poison control center or emergency services without delay.



Storage

Store Wellbutrin SR at room temperature between 68-77 degrees F (20-25 degrees C) in a dry place away from direct light, heat, and moisture. Do not store your medications in the bathroom or near a kitchen sink. Keep the tablets in their original packaging until ready to use. Keep all medications out of reach of children and pets. Do not use bupropion after the expiration date printed on the packaging.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug interactions, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.